The restaurant is aptly named after the highway A16 that winds through Campania the region that is home to Napoli, Positano, Pompei, the islands of Capri and Ischia that lie off the coast among many other lovely towns.

This restaurant is currently one of my haunts when I am in San Francisco; I really enjoy it!.
They have a wood-fired oven serving Neapolitan Pizza, which I will not delve into since there are so many varieties. Please check with the A16 website link above for the full menu and wine list.

Some of the interesting dishes served (some may be seasonal) are:
Beet and potato salad with radicchio, green olives and toasted almonds, Roasted young favas with green garlic, mint, chiles and lemon, Tripe napoletana with onions, tomato, white wine and breadcrumbs, La Quercia Berkshire prosciutto, La Quercia acorn edition tasting: coppa, lonza and lardo, Prosciutto San Daniele aged months,Smoked trotter terrina (house-cured), Ciccioli (house-cured),Pig ear terrina (house-cured), Lonza (house-cured), Bresaola (house-cured).

The wine bar serves around 40 wines by the glass or 375ml carafe and are mostly Italian with a few special boutique California wines, some made from Italian varietals.
I include only a few wines by the glass from Campania, although they have so many more, again check with the above website for the complete list:

White Wines: Glass or Carafe (375ml)
Campania Whites
Villa Raiano, Fiano di Avellino 2006,Terredora di Paolo, Greco di Tufo 2006, Alois,’Caulino’, Falanghina 2005, Marisa Cuomo, ‘Ravello’, Costa d’Amalfi 2006 (Falanghina/Biancolella)

The parking can be quite difficult so I would highly suggest going by taxi rather than spending time looking for street parking (very difficult) or big money to park in the lot